Retired history instructor. Alzheimer’s disease researcher for the past two decades.My goal is to give investors solid advice based on the mechanisms of action of Alzheimer’s drugs. This advice is informed by a background in biology (conservation, ecology, evolution, environmental science, and biochemistry) and twenty years of a very in depth review of the research on Alzheimer’s disease. I have come to the conclusion that Alzheimer’s disease is caused by oxidation and nitration. Many treatments for Alzheimer’s disease address factors that can contribute to oxidation and nitration such as misfolded amyloid and tau proteins and neuroinflammation, but very few direct scavenge compounds (such as hydrogen peroxide and peroxynitrite) that cause oxidation and nitration nor do they reverse any of the damage already present. Thus, most treatments for Alzheimer’s disease only slow down the early progression of the disease for awhile. Certain natural products such as panax ginseng and various essential oils via aromatherapy inhibit oxidation and nitration, scavenge agents that cause oxidative and nitrostative stress, and reverse part of their damage. Such treatments have the potential to stabilize Alzheimer’s disease.I follow companies, such as Anavex and Cyclo Therapeutics, whose drug candidate may do the same. These are the only Alzheimer’s companies that I recommend investing in.
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